Brentford's recent revival was brought to a halt as Northampton Town picked up the points with a 1-0 win at Griffin Park.
A tremendous 35-yard strike from Jason Crowe was the difference between the sides as The Cobblers ended The Bees' three game winning streak.
The only goal came after a disappointing first half hour, where chances had been few and far between.
Crowe picked the ball up as Brentford failed to clear the lines and he lashed an unstoppable drive past Nathan Abbey.
The Cobblers could have taken the lead earlier when Jordan Robertson picked the ball up in the inside left channel, cut inside and curled an effort against the crossbar.
Kenny Deuchar brought a save from Abbey as the visitors started the better and when Crowe broke the deadlock it was probably what they deserved.
But Brentford fought back, Charlie Ide had an effort deflected wide and from the resulting Joe Keith corner Garry Richards nodded narrowly past the post.
Abbey produced a double save from Sam Aiston and Robertson just before the break to keep Brentford in it and they had chances after the re-start to pull level.
Substitute Paul Brooker almost created an equaliser with his first touch, his delightful cross picked out Neil Shipperley and Mark Bunn was forced into a fine save high to his left.
Ide lashed a shot straight at Bunn while at the other end Abbey saved from Andy Holt and Andy Kirk almost caught The Bees' goalkeeper out from the right wing but shot into the side netting.
Jo Kuffour shot across the face of goal but it was the visitors who looked more likely to score.
Abbey saved well from Deuchar and Kirk and the latter also headed wide when well placed.
Try as they might Brentford couldn't get a foothold in the game and despite a lot of possession they ended up empty handed.
Brentford: Abbey; Osborne (sub Brooker 62 mins), Frampton, Richards, Tillen (sub Griffiths h/t); Ide (sub Willock 79 mins), Mousinho, O'Connor, Keith; Kuffour, Shipperley
Subs (not used): Nelson, Pinault
Northampton Town: Bunn, Pearce, Hughes, Doig; Crowe, Aiston (sub Taylor 72 mins), Hunt (sub Laird 90 mins), Johnson, Holt; Deuchar, Robertson (sub Kirk 66 mins)
Subs (not used): Dunn, Dyche
Bookings: Hunt (33 mins)
Attendance: 5,164 (303 away fans)
Written by Chris Wickham