During Brentford's 1-0 win at Portsmouth on Tuesday, Club Captain Kevin O'Connor was taken from the field on a stretcher.
It came days after the anniversary of an injury he sustained in an FA Cup with Budweiser tie against Basingstoke Town that caused him to miss more than six months of the 2011/12 season.
Brentford Football Club Head of Medical Neil Greig is now in a position to update supporters on the injury suffered by Kevin.
Neil said: "On Tuesday night against Portsmouth Club Captain Kevin O'Connor sustained a significant ankle and lower leg injury when falling awkwardly in a tackle, leading to him being stretchered from the field.
"Following scan investigations and consultation with a leading orthopaedic specialist, it has been established that Kevin will need to undergo surgery to repair the damage he has sustained.
"Kevin will undergo this surgery on Tuesday and then begin, what is anticipated to be, a six-month period of rehabilitation.
"Having worked closely with Kevin through his rehabilitation from long-term injury last season, I have absolute belief that he will return from this disappointing setback to play a key role for Brentford Football Club.
"Kevin demonstrates a first class attitude to recovery and we will offer him every support in order for him to complete his recovery."